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Simon Nicholls, aged 55, is another person with Alzheimer’s who is featured in the CNN documentary and who took part in the trial. Nicholls carries two copies of a gene variant called ApoE4 , which is known to significantly increase the risk of Alzheimer’s. However, after adopting healthy lifestyle changes, Nicholls saw remarkable improvements in his symptoms.
About 25 percent of the population carry at least one copy of the ApoE4 gene variant (called an allele) and 5 percent carry two copies . Carrying one ApoE4 allele is associated with a three to four times increased risk of developing Alzheimer’s. Carrying two copies increases the risk up to 12-fold , rendering it the greatest genetic risk factor for Alzheimer’s.
These statistics amplify the remarkable and noteworthy nature ofNicholls’s achievement in reversing his symptoms of Alzheimer’s simply through his lifestyle choices. His biomarkers for Alzheimer’s disappeared in 14 months, which is considerably more effective than most treatments for Alzheimer’s.